Placebo-controlled procedural trials for neurological conditions

Placebo controlled trials.

Researchers assessed the efficacy of varenicline (a licensed cigarette smoking cessation aid) in helping users of smokeless tobacco to quit. A double blind placebo controlled parallel group randomised controlled trial study design was used. The intervention was varenicline 1 mg twice daily. Treatment was delivered for 12 weeks, with 14 weeks’ follow-up afterwards. Participants were aged 18 year...

placebo-controlled trials in osteoporosis: ethical challenges

0

Placebo-Controlled Trials in Surgery

This systematic review was performed to investigate the ethical justification, methodological quality, validity and safety of placebo controls in randomized placebo-controlled surgical trials.Central, MEDLINE, and EMBASE were systematically searched to identify randomized controlled trials comparing a surgical procedure to a placebo. "Surgical procedure" was defined as a medical procedure invol...

Exploiting subjects in placebo-controlled trials.

Ethics and science of placebo-controlled trials.

Readers of this journal might not stop to categorize their responses as communitarian rather than individualistic, but there are probably very few readers from either the clinical or basic research domains who would quibble with the ethics of using a placebo or a control in experiments. Most would regard it as unethical to do an experiment in animals or humans that was not properly controlled s...